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Clinical trials Medicine

How not to predict the outcome of clinical trials

Yesterday, I came across a concept that I had never considered before (or even heard of before). In fact, it’s a concept that took me by surprise. Basically, it’s an application of a concept to a problem that I never considered applying the concept to before–probably with very good reason. Basically, it’s a guy named […]

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Clinical trials Complementary and alternative medicine Homeopathy Medicine Quackery

Homeopathy and “plausibility bias” versus science

One of the things that distinguishes evidence-based medicine (EBM) and science-based medicine (SBM) is how the latter takes into account prior probability that a therapy is likely to work when considering clinical trials. My favorite example to demonstrate this difference, because it’s so stark and obvious, is homeopathy. Homeopathy, as regular readers of this blog […]

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Antivaccine nonsense Clinical trials Medicine

Better late than never: The Dunning-Kruger effect meets an incompetent anti-vaccine “analysis”

It never ceases to amaze me just how ignorant of very basic principles of science anti-vaccine activists often are. I mean, seriously. Every time they try to post something, whether they know it or not, they end up making themselves look so very, very stupid–or at least ignorant. The Dunning-Kruger effect takes over, and people […]

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Cancer Clinical trials Complementary and alternative medicine Medicine

“Natural” versus CAM “natural”

NOTE: I was on a lovely vacation for three days in Chicago over the weekend, where I visited old haunts. (Bathroom attendants? At one of my favorite pub hangouts when I lived in Lincoln Park, John Barleycorn? Handing out crappy brown paper towels? Plastering the walls there with endless rows of flat screen TVs turned […]

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Clinical trials Medicine Science Skepticism/critical thinking

Scientific fraud and journal article retractions

A week ago, I took someone who has normally been a hero of mine, Brian Deer, to task for what I considered to be a seriously cheap shot at scientists based on no hard data, at least no hard data that he bothered to present. To make a long, Orac-ian magnum opus short, Deer advocated […]