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Biology Clinical trials Evolution Medicine Physics Science Skepticism/critical thinking

Is the “decline effect” really so mysterious?

NOTE: Orac was actually out rather late last night. It turns out that the more administrative responsibility he somehow seems to find the more he has to go out to dinner as a part of various cancer center-related functions. As a result, he is recycling a bit of recent material from elsewhere that he in […]

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Clinical trials Humor Medicine

Sadly, this is not too far from the truth for my basic science colleagues…

It’s times like these that I’m glad I’m a clinician-scientist: Or maybe not. The reason is that the same conversation in a clinician-scientist’s review would be asking why he’s only produced X number of RVUs last year and suggesting pointedly that he needs to double his RVU output. Oh, and, by the way, he needs […]

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Cancer Clinical trials Medicine

The toll due to secondhand smoke

Given that I’ve dedicated my life to treating cancer and researching the biology of cancer, the ultimate goal being to use that knowledge of cancer biology to develop ever more effective treatments directed at the specific molecular derangements that lead to cancer, it’s not surprising that I’m very much anti-tobacco. After all, arguably there is […]

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Clinical trials Complementary and alternative medicine Medicine

Integrating patient experience into research and clinical medicine: Will this lead to true “personalized medicine”?

I advocate science-based medicine (SBM) on this blog. However, from time to time, consider it necessary to point out that SBM is not the same thing as turning medicine into a science. Rather, I argue that what we do as clinicians should be based in science. Contrary to what some might claim, this is not […]

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Clinical trials Complementary and alternative medicine Homeopathy Medicine Quackery

What’s in a placebo? Mike Adams certainly doesn’t know.

If there’s one thing that confounds advocates of so-called “complementary and alternative medicine” (CAM), it’s the placebo effect. That’s because, whenever most such remedies are studied using rigorous clinical trial design using properly constituted placebo controls, they almost always end up showing effects no greater than placebo effects. That’s the main reason why they frequently […]