Last week blew by me in a blur. Because I was in full grant writing frenzy to get an R01 in the can by Friday, pretty much anything that wasn’t totally urgent got shoved aside, at least after Wednesday. Of course, it was last Wednesday that yet another mammography study was being touted as a […]
Category: Clinical trials
One of the favorite fallacious arguments favored by pseudoscientists and denialists of science is the ever infamous “science was wrong before” gambit, wherein it is argued that, because science is not perfect or because scientists are not perfect, then science is not to be trusted. We’ve seen it many times before. Indeed, we saw it […]
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If there’s one thing that burns me about so-called “complementary and alternative medicine” (CAM) clinical trials, it’s how unethical many of them are. This is particularly true for trials that test modalities that, on the basic science grounds alone, can be dismissed as so highly implausible and with such a low prior probability of success […]
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Unfortunately, it’s grant application crunch time again over the weekend. That means something’s got to give, and what happened to be the thing to give was this blog. Fortunately, all is not lost, as a “good friend” of mine has commented on a recent New England Journal of Medicine study from Thursday about mammography. It […]
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A critical aspect of both evidence-based medicine (EBM) and science-based medicine (SBM) is the randomized clinical trial. Ideally, particularly for conditions with a large subjective component in symptomatology, the trial should be randomized, double-blind, and placebo-controlled. As Kimball Atwood pointed out just last week (me too), in EBM, scientific prior probability tends to be discounted […]
