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Clinical trials Medicine Personal Politics Popular culture Skepticism/critical thinking

Henry Ford Hospital hydroxychloroquine trial: Not good evidence that the drug works for COVID-19

Recently, Henry Ford Hospital published a study of hydroxychloroquine for COVID-19 that showed a benefit. Unfortunately, it was a bias-prone retrospective study. That didn’t stop President Trump from touting the drug again.

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Cancer Clinical trials Medicine Quackery

Acupuncture for xerostomia: Spin, spin, spin a negative study!

Investigators at M.D. Anderson Cancer Center reported the results of a trial of acupuncture for xerostomia (dry mouth) secondary to radiation therapy for head and neck cancers. It was a negative trial, but investigators still tried to spin it as positive, but with a twist. There was a large difference between results found at M.D. Anderson and the second site in China. What could be going on?

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Bad science Bioethics Clinical trials

Pay-to-play clinical trials: The HHS Secretary’s Advisory Committee on Human Research Protections (SACHRP) weighs in

The ethics of pay-to-play clinical trials are a minefield. Last week the HHS Secretary’s Advisory Committee on Human Research Protections (SACHRP) stepped into that minefield. Are “pay-to-play” clinical trials ever ethically acceptable?

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Clinical trials Complementary and alternative medicine Integrative medicine Medicine Skepticism/critical thinking

A bait-and-switch study of acupuncture in stable chronic angina

This week, JAMA Internal Medicine published a clinical trial purporting to find that acupuncture helps stable angina. Here’s a hint: It doesn’t. It’s a bait-and-switch study that used “electroacupuncture” instead of acupuncture with poor blinding and lack of consideration of prior plausibility.

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Clinical trials Complementary and alternative medicine Integrative medicine Medicine Quackery Skepticism/critical thinking

Chiropractor Anthony Pellagrino touts a dubious study of chiropractic for stroke

“Dr.” Anthony Pellagrino is a chiropractor who fancies himself a scientist. Unfortunately, his touting a dubious study of chiropractic for stroke shows that he doesn’t know a crappy study when he sees it.