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Antivaccine nonsense Clinical trials

“No saline placebo-controlled vaccine trials”: An old antivax trope

Robert F. Kennedy, Jr. has resurrected the antivax claim that the childhood vaccine schedule has never been tested in randomized controlled trials (RCTs) with a saline placebo controls (and therefore the vaccine schedule is unsafe). This is an old and deceptive antivax half-truth that ignores both what constitutes a scientifically valid placebo and the ethical requirements for RCTs.

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Antivaccine nonsense Clinical trials Medicine

Undermining the childhood vaccine schedule with EBM fundamentalism

“Not antivax” COVID contrarian Dr. Vinay Prasad demonstrates why skepticism is necessary and how evidence-based medicine (EBM) fundamentalism harms childhood health by inadvertently (I hope) echoing a very old antivax trope about randomized clinical trials for the childhood vaccine schedule, you know, to “rebuild confidence.”

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Antivaccine nonsense Medicine Politics Popular culture

Return of the revenge of “no saline placebo RCTs” for childhood vaccines

Thanks to RFK Jr. the deceptive claim that the childhood vaccine schedule has never been tested in a randomized controlled trial with a saline placebo control is making the rounds again.This is an old and deceptive antivax half-truth that ignores both what constitutes a scientifically valid placebo and the ethical requirement that RCTs have clinical equipoise.

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Clinical trials Homeopathy Medicine Quackery

Why are so many clinical trials of homeopathy “positive”?

Homeopathy is The One Quackery To Rule Them All. Why, then, can homeopaths seemingly cite so many “positive” randomized clinical trials to support it?

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Clinical trials Medicine Science Skepticism/critical thinking

What next for the randomized controlled clinical trial?

One of the most frequent complaints about evidence-based medicine (EBM), in contrast to science-based medicine (SBM), is its elevation of the randomized clinical trial as the be-all and end-all for clinical evidence for an intervention for a particular disease or condition. Unknown but enormous quantities of “digital ink” have been spilled explaining this distinction right […]