Evidence-based medicine (EBM) has been a very useful paradigm for assessing evidence in medicine. However, like any other framework, it can be misused, particularly when fundamentalist EBM methodolatry leads to its inappropriate application to questions for which it is ill-suited, a misuse that has been weaponized against public health during the pandemic.
Earlier this month the Cochrane Collaborative was forced to walk back the conclusions of a review by Tom Jefferson et al that had been spun in the media as proving that “masks don’t work.” Tom Jefferson himself has been problematic about vaccines for a long time, but the rot goes deeper. What is it about the evidence-based medicine paradigm that results in misleading conclusions?
In order portray COVID-19 vaccines as dangerous, Peter Doshi has now managed to get poorly designed and performed “reanalyses” of the clinical trial data used by the FDA to grant emergency use approval of the Pfizer and Moderna vaccines published in two reputable journals, The BMJ and Vaccine? What happened?
